Our current understanding of the pharmacological properties of CBD and how it relates to bruising
When Ponce de Léon set out on his expedition in 1513, he steered his sights towards what is now modern-day Florida in search of the Fountain of Youth.
When Elon Musk started Neuralink, his expedition was aimed at finding a way to preserve consciousness after the death of a body.
Even though we may never find it, we all would like to find the answer to aging and mortality.
At this point in our long history of searching, we’d settle for a panacea.
But, are we placing too much faith in cannabinoids?
We’ve recently come across claims that CBD salves help with bruising, but is it true?
Inflammation in Bruising
CBD has been well documented to help with inflammation.
Topical application of CBD, according to a 2016 study published in the European Journal of Pain, attenuate symptoms of arthritis, including the associated inflammation .
However, this type of inflammation is a natural immune response. Per a 2018 article in the journal, Cell Immunology, CBD helps reduce pro-inflammatory markers such as cytokine and chemokine responses .
When it comes to bruising, the inflammation arises for a separate reason.
The authors of a 2013 paper—which was published in Oxidative Medicine and Cellular Longevity—outlined bruises in a clear way .
They noted that the endothelium is integral to inflammation during bruising.
They said that the endothelium “has a pivotal role in the inflammatory response mainly by inducing the leukocyte adhesion cascade to facilitate the transmigration of inflammatory cells to the inflamed tissue.”
Is there some way CBD can help with bruising, if not via inflammation?
Bruise. Pain. CBD Salve.
According to the 2016 article from the European Journal of Pain, topical CBD not only helps with inflammation, but pain as well.
A 2018 article supported the idea by noting that those suffering from chronic pain, musculoskeletal pain, and even pediatric patients benefit from topical CBD applications .
There’s a chance that CBD may assist with the pain associated with bruising, but the evidence isn’t yet clear.
CBD Salves and Bruising Busted
You don’t have to be a famous explorer or inventor of rocket ships to strive for your healthiest, longest life.
But that doesn’t mean we should exaggerate the effects of cannabinoids.
They’re marvels of nature in their own right, and we should all thank the first explorer who ventured into the world of consuming cannabis.
- Hammell DC, Zhang LP, Ma F, et al. “Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.” Eur J Pain. 2016. 20(6):936–948. [Times cited = 47; Journal Impact Factor = 3.188]
- Li H, Kong W, Chambers CR, et al. “The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice.” Cell Immunol. 2018. 329:1–9. [Times cited = 3; Journal Impact Factor = 3.219]
- Jeney V, Eaton JW, Balla G, Balla J. Natural history of the bruise: formation, elimination, and biological effects of oxidized hemoglobin. Oxid Med Cell Longev. 2013. 2013:703571. [Times cited = 33; Journal Impact Factor = 4.868]
- Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018. 23(10):2478. [Times cited = 12; Journal Impact Factor = 3.060]